CBD innovative development has become an important way to converse previous regional kinetic energy into the new one and fuel the engine of economic growth. This paper makes an index-supporting analysis on CBD transformation and its innovative development from four perspectives：integrative development，regional radiation，building economy and business environment. Meanwhile，it makes a comprehensive analysis on the industrial development of several major central business districts in China and their way to lever CBD upgradation by innovation driven development. The conclusion indicates that CBD has achieved remarkable results in financial reform innovation，building-economy improvement and the improvement of CBD vitality. In the first half of 2020，CBD has made great efforts to apply innovative technology to improve epidemic-prevention and control capability so as to reduce the loss of covid-19，and takes active measures to encourage enterprises to start work resumption. Also，the paper analyses the challenges faced in promoting CBD development，which involves poor cooperation between business technological research departments，the manufacturing organizations and the relevant universities and college. The challenges include poor financial ecological environment，slow the response of building economy to epidemic management. These challenges restricted space for technological enterprises to develop their industries，too. Hence，some countermeasures and suggestions have been proposed to encourage the local governments to construct innovation platforms，to establish new institutions of tech-introduction and to find the ways to optimize financial ecological environment.