In 2014，China became a net foreign investor，and going abroad with science and technology is an important cornerstone of high-quality international development. Bay area in the development of an important kinetic energy is kechuang，large bay sea of science and technology including infrastructure supporting exports，products in the process of “going out” to “go out” competition - reversed transmission to drive enterprise innovation research and development，the reverse development and acquisitions overseas research and development，the “region” business model innovation，etc，this paper summarizes the influence of science and technology of “four factors model”，and further analyzes the large bay area related out the advantages and disadvantages of the enterprise，the large sea bay area enterprise has carried on the analysis of development trend.