Guangdong is the window of China’s reform and opening-up，and the cooperation between Guangdong，Hong Kong and Macao is the representative of the fruitful results achieved in China’s reform and opening-up. In the process of cooperation between Guangdong，Hong Kong and Macao，the mode of cooperation has changed from “front shop and back factory” to “CEPA framework” and now to “collaborative development”. The first two stages laid a solid foundation for the synergetics behind Guangdong，Hong Kong and Macao，and achieved close cooperation between manufacturing and service industries. At present，with the formulation of the development plan for the Guangdong-Hong Kong-Macao Greater Bay Area，Guangdong，Hong Kong and Macao have ushered in a new stage of development. Through the analysis of the cooperation foundation，market division and system arrangement of Guangdong，Hong Kong and Macao，this Paper provides corresponding theoretical support for the collaborative evolution development of Guangdong，Hong Kong and Macao at the present stage.