General Secretary Xi Jinping has repeatedly stressed：“To create a good financial environment for real economic development，to open up channels for financial access to the real economy，to actively standardize the development of multi-level capital markets，to expand direct investment，to strengthen credit policy guidelines，to encourage financial institutions to increase financial support for advanced manufacturing and other fields，and to promote supply-side structural reform.”“In the context of public entrepreneurship，innovation for all”，Shenzhen as a “first demonstration area” should take the lead in the financial industry innovation and development to try. The Nanshan District of Shenzhen responds to the call，deeply implemented the national policy，vigorously developed science and technology finance，gradually perfected the scientific and technological financial ecology，integrated the government，banks and other subjects，enriched scientific and technological financial products，take new measures，create new achievements，sort out new models，and make every effort to provide financial services for small and medium-sized science and technology enterprises. But at the same time of rapid development，there are also some problems in Nanshan District’s science and technology finance，such as the imperfect supervision system of science and technology finance，the need for technology upgrading of traditional security risk control，and the relative shortage of talent supply of science and technology finance，which is also analyzed and put forward suggestions for future development.