In recent years，the “digital revolution” set off worldwide has profoundly affected all aspects of economic society. Digital trade is a concept spawned by the deep binding of the digital economy and opening-up. It is a new form of trade that emerges from the close integration of information technology with trading methods and products. With the continuous expansion of the global digital trade scale and the development of globalization to a higher stage，the transformation and upgrading of the central business district （CBD） has ushered in new opportunities for achieving high-quality and sophisticated development. However，at this stage，the development of CBD digital trade is also faced with issues such as unclear industry boundaries，unclear management subjects，and other urban functional areas’ competition against CBD in the field of digital trade. This requires CBD to actively adapt to the needs of digital development，further clarify its strategic positioning，standardize industry definition，improve policy systems，optimize infrastructure，improve the level of opening-up，release the digital dividend more widely，and comprehensively improve the quality and level of the development of the CBD digital trade.