In 2020，the COVID-19 epidemic have disrupted the normal working and living rhythm of Chinese people. The work of epidemic prevention and control was examined by 1.4 billion Chinese people in the public opinion field. With the change of epidemic situation at home and abroad，the theme of public opinion is constantly changing. In the early stage of Covid-19 outbreak，there was a shortage on medical resources in Wuhan，and the public questioned the local government’s ability to control the public health crisis. After the central government mobilized national resources to help Wuhan，the epidemic prevention and control war achieved significant strategic results，especially in contrast to the epidemic spread in the United States，and public opinion highly recognized China’s institutional and cultural advantages. Trump administration blamed and blocked China，and China-US relation declined，which caused the anger of domestic public，as well as deep worries about globalization，international supply chain and independent innovation of science and technology.