The global supply chain is accelerating the reconstruction under the influence of the multiple forces from home to abroad. How can cross-border e-commerce turn crisis into opportunity of supply chain reconstruction as the major mode of trade in the future？And how to take the initiative and seize the opportunity to achieve high-quality development？This paper analyzes the trend of supply chain reconstruction and the risks and challenges，it is believed that maintaining the stability of the global supply chain is the basis for international trade such as cross-border e-commerce. Then it analyzes the challenges of cross-border e-commerce from supply chain construction and discussing the development opportunities. Finally，it proposes the countermeasures and suggestions on how to realize the high-quality and innovative development of e-commerce from six aspects：creating a better international business environment，improving the digital level of cross-border e-commerce，focusing on the collaborative development of cross-border e-commerce with logistics，innovating the financial service mode，improving the service quality with blockchain technology，and providing guarantee for the high-quality development of cross-border e-commerce.