In this era，with the rapid development of information technology such as the Internet，big data and artificial intelligence，people’s lifestyle and consumption concepts have also undergone great changes，especially in the continuous upgrading of healthy，green and personalized consumer demand，which has created a huge space for the transformation and development of the food processing industry in Henan province，but also brought unprecedented opportunities and challenges. Under the new situation，Henan province，as a major agricultural province and a large food processing province，must conform to the trend of the times，vigorously promote the food processing industry to high-end，green，intelligent，integrated transformation and upgrading，to help Henan’s economy to achieve high-quality development，so as to achieve a great leap from agricultural province to strong agricultural province. This paper first expounds the significance of the integration of entrepreneurship，innovation，and creation to the transformation and development of the Henan food processing industry，then analyzes the current situation and problems of the Henan food processing industry under the new situation，and finally puts forward some suggestions from the perspective of entrepreneurship，innovation，and creation integration，so as to advance the transformation and development of the Henan food processing industry.