The construction of private university think tanks and the coordinated development of local economy will help improve the local economic decision-making consultation service system. The research on the coordinated development of private university think tank construction and local economy can well promote the modernization of local economic management mechanism and management means，which is also the goal and power of domestic private university think tank construction in the new stage. In this paper，by consulting literature，collecting relevant information，taking private colleges and universities in Henan Province as research cases，and conducting investigation by means of interview，we found that at present domestic private colleges construction and the coordinated development of regional economic think-tank，has many problems and difficulties in the process，finally，this paper from the “market”，construct scientific mechanism of coordination with economic think-tank，based on “innovation drive”，change think-tank，serving local economic system，based on the “decision” practice，ensure think-tank docking services local economic development needs，based on the tenet “skills”，introduction of science-based think-tank researchers from four aspects，The strategy of synergetic development between private university think tank construction and local economy is put forward.