Ionizing irradiation technology is an emerging environmental pollution treatment method，and its basic principle is to use the direct action of high energy rays（radioactive nuclides，such as gamma rays generated by 60Co or 137Cs，or electron beams generated by electron accelerators）and indirect action（hydroxyl radicals，hydrogen radicals，hydrated electrons and other active particles generated by water molecule radiation decomposition）to destroy or degrade pollutants. This report studied the treatment of erythromycin and cephalosporium residues by ionizing radiation. The results showed that ionizing radiation could not only degrade the antibiotic remaining in the residues，but also kill drug-resistant bacteria and eliminate resistance gene contamination，thereby achieving harmless treatment of antibiotic residues. In addition，ionizing irradiation had no significant effect on the protein and polysaccharide components in antibiotic residues. The residues treated by ionizing irradiation can retain their nutrient components，which could be used for the preparation of feed or organic fertilizers to achieve the recycling of antibiotic residues. Demonstration project of harmless treatment of antibiotic residues by electron beam irradiation（daily treatment capacity of about 5000 tons of wet residues）started its construction in Chuanning Biotechnology Company in Yili，Xinjiang.