Wastewater produced in fermented antibiotic production usually has high-concentration antibiotic residues. The presence of high-concentration antibiotics not only severely inhibits the activity of wastewater treatment microorganisms and affects the effect of wastewater treatment，but also leads to the production of a large number of antibiotics and resistance genes in the biological treatment of wastewater，making wastewater treatment systems an important discharge source of resistance genes to the environment. This report firstly proposed the concept of residual antibiotic titers in wastewater from high-concentration antibiotic production. On this basis，it elaborated the method of intensified hydrolysis pretreatment to eliminate antibiotic titers in wastewater and then combine biological and physicochemical methods to remove conventional pollutants. Eliminating the antibiotic titers of wastewater can not only relieve the inhibition of antibiotics on wastewater treating microorganisms，to ensure the effect of biological treatment of wastewater，but also prevent the production of resistance genes in the process of biological treatment of wastewater，to ensure the synergistic control of antibiotics，resistance genes and conventional pollutants. And it proposed the future development direction of such wastewater treatment and environmental management，with a view to providing technical support and scientific basis for the sustainable development of the pharmaceutical industry.