In 2019，China’s food and drug safety regulatory reform has been continuously deepened under the new “big market—special drug” system，and the reform of “regulation and service” has been actively promoted. Comprehensive law enforcement reform has achieved initial results，and the supervision in key areas has been strengthened. In general，it shows the characteristics of accelerated system construction，improved supervision efficiency，comprehensive transformation of supervision mode and continuous innovation of supervision mechanism. However，there are still some weak relations. The next step is to strike a balance between industrial development and safety supervision，comprehensive supervision and professional supervision，regulatory authority and regulatory capacity，food and drug regulatory departments and general market regulatory departments，provincial drug regulatory agencies and market regulatory departments below the provincial level.