The core of Sino-US trade friction is the protection of intellectual property rights. This report collects and sorts out background information，trade data，and negotiation process and results of five trade-related Sino-US intellectual property disputes that occurred in 1991，1994，1996，2007，and 2017，and get conclusions as follows. First，the difference in the structure of Sino-US trade is the key to forming a Sino-U.S. trade deficit. One of the main reasons is that the United States prohibits the export of high-tech products to China. Second，the number of intellectual property dispute settlement negotiation rounds has been increasing，showing the trend of catching up with China’s high-tech development. Third，the results of previous negotiations on the settlement of trade-related Sino-US intellectual property disputes are a realistic choice between China and the United States. More impotently，it is a process of continuous improvement of China’s intellectual property system. Finally，it is expected that there will be a long-term trend in Sino-US intellectual property disputes，and China’s intellectual property protection system is in line with international standards in the process of construction and improvement.