This report matched the list of products subject to tariffs on China’s exports published by the Office of the United States Trade Representative （USTR） with data at the micro level. It was found that the first three rounds of tariffs would reduce Guangdong’s exports by 0.22%-3.45%. The fourth round of tariffs will reduce Guangdong’s exports by 0.09%-1.38%. Compared with the first three rounds of tariffs，the fourth round of tariffs will have a greater impact on Guangdong’s processing trade and the wholly foreign-owned enterprises. In addition，different industries and cities will be affected differently. Finally，the report gives Guangdong’s suggestions for coping with Sino-US trade frictions in terms of further deepening reform and opening up，reducing corporate costs，and promoting market diversification.