This report presents the characteristics of Guangdong-Africa import and export trade and two-way direct investment，the advantages and problems of Guangdong-Africa economic and trade cooperation at this stage，and several suggestions for future economic and trade cooperation based on the analysis. This report analyzes the development of economic and trade relations between Guangdong and Africa. From the analysis，we have drawn the following conclusions. First，in the future，Guangdong-Africa economic and trade cooperation will develop with non-direct investment as the main model and carrier，especially under the “Belt and Road” initiative. The second is that Guangdong-Africa economic and trade cooperation needs new points of trade growth to change the current single trade cooperation model. The third is that the role of the government will be more important in Guangdong-Africa economic and trade cooperation. Fourth，the construction of the Guangdong-Africa Free Trade Zone will be an effective growth point for both sides’ economic and trade development，but the construction still has a long way to go. Fifth，the continuous upgrading of China’s industrial structure will inevitably lead to closer economic and trade cooperation between Guangdong and Africa；Economic and trade cooperation. Sixth，we should also pay attention to coordination with other countries when building the cooperation with Africa，which can create a win-win platform.