The innovation of commercial registration system is an important measure to further improve the market supervision system in Shenzhen. In view of the problems existing in the withdrawal mechanism of commercial subjects，it is necessary for Shenzhen to make institutional innovation by using the legislative power of the special zone，including the establishment of de-listing system，compulsory cancellation system and simple cancellation system，the cancellation of pre-approval of enterprise names，the reduction of registration filing items and registration materials，the establishment of commercial registration contact person system，the clarification of legal liability for false registration，and so on，to promote the improvement of the commercial registration system.