Based on the local situation of Guangzhou，this report conducts an online questionnaire which is named Questionnaires of Assessing Happiness of Guangzhou Municipality’s Residents compiled in 2013 and adopts the stratified and cluster random sampling to research on 2714 residents of Guangzhou. At the same time，we compared it with the data of 2017 and 2018. The results show that：（1）Guangzhou residents have the highest degree of satisfaction in the dimension of spiritual life and the lowest degree of satisfaction in the dimension of social equity. Overall happiness is above average；（2）The seven happiness indicators of Guangzhou residents are influenced by factors such as gender，age，residence time，living area，marital status，education level，occupation type，number of real estate，monthly income and monthly consumption level etc.；（3）At present，the relative deprivation of Guangzhou residents is still relatively common，and there are differences among different social groups；（4）Spiritual life is the most crucial factor affecting the improvement of residents’ happiness. The quality of life has maximum correlation with residents’ happiness. The residents most hope to improve their Social equity and quality of life；（5）According to the happiness data in the recent three years，the overall happiness and the score of the seven dimensions of Guangzhou residents in 2019 have improved significantly compared with that in 2017，while is basically the same as that in 2018. On account of the above investigation results，this report proposes relevant suggestions for how to further promote the happiness of Guangzhou’s residents.