In the process of retrospective depicting the communication innovation of media social responsibility，this paper mainly analyzes two kinds of empirical materials of 42 reports on media social responsibility from 11 mainstream media：one is to define and discuss“what is media social responsibility”；The second is the practice of media innovation centering on“social responsibility of media”.This paper attempts to answer the question：in the age ofomnimedia，how can the media innovatively fulfill the social responsibility of media communication practice？This paper will adopt a clear set of qualitative comparative analysis method（cs-QCA）qualitative empirical research，from the evaluation main body，index system of quantitative standard and the evaluation scope，evaluation results and so on study of the mainstream media social responsibility how to implement the cause of innovative communication practice，as well as the interactive relationship between innovation factors，possibility condition combination，and how to through the genetic combination stimulate the innovation of the media social responsibility practice.Through the innovation reform of China's mainstream media industry，we fully advocate and regulate the communication practice of social responsibility.On the one hand，we rely on artificial measures such as news ideal and system mechanism；on the other hand，we start from the logic of technology，the silent and compulsory evolution of strict scientific and technological procedures，and abandon the thorough reform of interest entanglement.