The emergence of new Psychoactive Substances challenges the legalization and constitution of the drug control system. How to control the new Psychoactive Substances，protect the rights of the citizens while in the same time contain potential threats to existing social order and avoid structural destruction of the existing drug control system is an important question. China has embarked on planning and building a new system for the new Psychoactive Substances regulation. Although China has made efforts in legislation and specific measures，but there are still some points to be reviewed and improved. The regulation system of new Psychoactive Substances in China should，based on the existing legal resources and international experience and reasonable plans，effectively control the new Psychoactive Substances without drastically changing the existing drug control system and measures.