The novel coronavirus pneumonia epidemic has a more extensive and far-reaching impact on the industrial base and industrial chain. Guangzhou must focus on the industrial chain to deploy innovative chains，focus on the industrial chain of the innovation chain，vigorously build a modern industrial system，and continuously upgrade the core competitiveness of the industry，so as to implement the Central Committee’s major deployment on doing a solid job in “six stability” and fully implementing the “six guarantees” task. The article summarizes the basic situation of Guangzhou’s industrial foundation，deeply analyzes the development of the industrial chain of some key industries，objectively analyzes the major shortcomings of the Guangzhou’s industrial foundation and the industrial chain，and combines the favorable conditions of the external environment to make a targeted suggestions for the promotion of Guangzhou’s advanced industry foundation and modernized industrial chain.