This study takes 18 typical microblog opinion leaders in different fields as the research object，and conducts quantitative statistical analysis on 2308 microblog information published to investigate the social responsibility performance of Weibo opinion leaders. The research shows that there is still room for improvement in the social responsibility performance of Weibo opinion leaders. The average score of the social leaders’ evaluation scores of the opinion leaders is 2.59356 （score rate is 51.87%），and the score is more than half of the full score. Weibo opinion leader “Information Production A1” scores are above average，but the performance of social responsibility in “value guidance A2”，“cultural education A3” and “coordination communication A4” needs to be further improved.