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谢伏瞻
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李培林
    男,汉族,出生于1955年5月,山东济南人,博士,研究员,全国人民代表大会社会建设委员会副主任委员,中国社会科学... 详情>>

    国内外人工角膜研究现状与发展趋势(1974~2018)

    摘要

    作为解决角膜盲绝症的唯一治疗方法,人工角膜在近20年中受到国内外角膜学科界的广泛关注。目前全球范围内,已研发出四种用于临床的人工角膜,分别为:波士顿型人工角膜、骨齿型人工角膜、MICOF型人工角膜、AlpharCor人工角膜,其中在全球范围内应用最广泛的是波士顿型人工角膜。在我国,虽然尚未有一款完全由人造材料合成的人工角膜上市,但来自中国人民解放军总院(三○一医院)、中山大学中山眼科中心和山东省眼科医院的眼科专家早已组成了研究团队,对人工角膜开展了20多年的研究,从而获得成熟的研究成果。现阶段,一款根据我国病患角膜及眼表结构特点自主研发生产的领扣型人工角膜已顺利完成一系列检测与临床试验,并取得满意的结果。预计领扣型人工角膜的上市,将会促进我国人工角膜研究中心的落成,从而推动我国人工角膜研究领域和角膜学科的发展。

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    Abstract

    As the only treatment for corneal blindness,artificial corneas have been widely applied in the corneal field at both home and abroad in the past 20 years. As of now,four kinds of artificial corneas have been created and developed for clinical application on a global scale,consisting of Boston Type Keratoprosthesis,Osteo-Odonto Keratoprosthesis,MICOF Keratoprosthesis and AlpharCor Keratoprosthesis,among which Boston type keratoprosthesis has been widely applied in the world. In China,although there is not any keratoprosthesis completedly made by artificial material synthesis on the market,Chinese ophthalmology experts from the General Hospital of the People’s Liberation Army(also known as Hospital 301),Zhongshan Ophthalmic Center of Sun Yat-sen University and Shandong Provincial Ophthalmic Hospital have formed a research team and plumbed the depths of research about artificial corneas for more than 20 years,thereby obtaining abundant results from researches. Nowadays,a Collar-buckle type Keratoprosthesis developed independently according to the the structural features of Chinese patients’ corneas and ocular surface has successfully completed a series of tests and trials,thereby reaching satisfactory results. Moreover,it is estimated that the launch of the Collar-buckle type Keratoprosthesis will promote the establishment of the the artificial cornea research center in China,thus promoting the development of the field of artificial corneas research and discipline of corneas in China.

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    作者简介
    史伟云:史伟云,教授,博士,山东省眼科医院院长。
    翟嘉洁:翟嘉洁,博士,广东佳悦美视生物科技有限公司总经理。
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