Through years’ construction and development，the Guangdong-Guangxi Interprovincial Pilot Cooperation Special Zone has witnessed outstanding results with clearer industry positioning，some achievements in the cultivation of “industrial trees”，better ancillary facilities，and initial formation of the interconnectivity. Efforts have been made to deepen reform and innovation and the business environment keeps being improved. However，some constraints still exist in the road to achieve high-quality development of the Guangdong-Guangxi Interprovincial Pilot Cooperation Special Zone. The institutional and structural innovation need to be further enhanced immediately，and so is the attraction of industries’ matching；innovation in the management of talent introduction is needed urgently，so are the improvement on investment and financing systems and a streamlined process of administrative approval. To advance the high-quality development of the Guangdong-Guangxi Interprovincial Pilot Cooperation Special Zone，it is necessary to further rationalize the interest balance mechanism，create a new operation and management model，focus on the development of key industries，speed up the establishment of a three-dimensional transportation network system，make innovations on the institutions of the management of science and technology and talents，and further strengthen the ability of finance to serve the real economy.