At present，it has become a basic task to scientifically prevent and effectively dissolve financial risks，strictly guard the bottom line against systematic financial risks，and continuously maintain the steady operation of the financial sector. With the age of big data coming，new opportunities for finance emerge to have an integrated development with technology. Besides，financial regulation will also be supplemented by scientific and technological innovation. Against this background，it has become a new research proposition to measure financial risk level and prevent and control financial risks in an innovative manner. After analyzing a large number of research literature and guided by representative theories，the paper tries to explore our levels of regional financial risks and the mechanism of risk prevention and control from the perspective of macro-prudential regulation and sustainable financial development，by establishing the theoretical model and index for the big data-based financial risk prevention and control.