“Enclave economy” refers to the breaking of administrative division restrictions in two different administrative regions，with the direct purpose of complementary and efficient use of production factors. Cooperative construction various of economies，industrial parks in specific regions，through construction，management，and benefit distribution. This paper analyzes the attempts and practices of the development of “enclave economy” in Suzhou，Shenzhen and other places for many years，sorts out and summarizes typical cross-regional cooperation models，and combines with the development reality of ZhongGuanCun Science City to propose an orderly guide for the industrial cross-regional layout Specific countermeasures.