With the vigorous development of new economy，Zhongguancun Science City is gradually becoming an important engine to support the development of national science and technology innovation center and the main source of new economy. Through the research and analysis of the current stage characteristics，key areas of concern and challenges faced by Zhongguancun Science City’s new economic development，around the cultivation of innovation subjects，the development of emerging industries，“High-precision” industrial spatial distribution，innovation mode exploration，reform and innovation of system and mechanism，the author puts forward suggestions and Countermeasures to promote the development of Zhongguancun Science City’s new economy.