The Grand Canal is a great project created in ancient China. It is a flowing and alive world-class human civilization heritage，which contains the long cultural genes of the Chinese nation. At present，there are still some problems in the cultural heritage protection and tourism development of the Grand Canal Cultural Belt. It is necessary to strengthen the top-level design，coordinate infrastructure construction，and improve the regional coordination mechanism；deepen the cultural connotation of the Grand Canal，create a cultural symbol of the canal；promote industrial integration，innovative culture heritage inheritance method to enrich the supply of cultural tourism products and services，and promote the Grand Canal Cultural Belt to become a symbolic cultural brand that promotes China’s image，displays Chinese civilization and demonstrates cultural self-confidence，and becomes a Chinese model for cultural protection inheritance and tourism development and utilization.