Improving energy efficiency and strengthening industrial layout adjustment can not only reduce the intensity of energy resource consumption，promote the green development of the Yangtze River Economic Belt，but also enhance the international competitiveness of the Yangtze River Economic Belt. This report quantitatively examines the temporal and spatial evolution characteristics of the manufacturing agglomeration level in the Yangtze River Economic Belt. It is found that the manufacturing location entropy of the Yangtze River Economic Belt has fluctuated and decreased in recent years，and the regional disparity is large. The manufacturing concentration in the middle reaches is generally high，with great Comparative Advantage. This report uses the general static panel model，the general dynamic panel model，and the multiple threshold regression model to examine the threshold effect of the Yangtze River Economic Belt manufacturing cluster. Based on the estimation results of different threshold effects，the impact of the total factor energy efficiency of the Yangtze River Economic Belt is further tested. Nonlinear characteristics. After crossing the threshold，market-oriented reforms can effectively promote the level of import and export trade and opening up. Government intervention can effectively promote energy conservation and emission reduction and green technology promotion. The improvement of economic development can effectively promote local governments to obtain sufficient fiscal revenue to support local low. Carbon development to improve energy efficiency. During the “Thirteenth Five-Year Plan” period，in order to promote the sustainable and healthy development of the Yangtze River Economic Belt manufacturing industry，it is necessary to promote the industrial clustering of the Yangtze River Economic Belt to the advanced stage，improve the government functions，promote institutional innovation，and play the role of the Yangtze River Economic Belt opening to the outside world.