Industry is the focus of high quality economic development. High quality industrial development is the top priority of the Yangtze river economic belt. Review the policy texts and practice hot spots of high quality industrial development in the Yangtze river economic belt from national and provincial levels. Based on the scientific connotation of industrial high quality development，this report builds a comprehensive evaluation system of industrial development quality including 36 indicators of innovation-driven，green transformation，coordinated development and open development. Based on panel data of 30 provinces in 2011-2017，Using the Entropy-Topsis method to assess the quality of industrial development in 30 provinces across the country，focusing on the relative position of the industrial development quality of the Yangtze River Economic Belt in the country，and combining the two spatial scales of the middle and lower reaches of the Yangtze River Economic Belt and the 11 provinces along the Yangtze River Economic Belt to analyze the Yangtze River economy. With the evolutionary characteristics and spatial differences in the quality of industrial development. The research results show that the quality of industrial development in the Yangtze River Economic Belt has been steadily rising，significantly higher than the national average and outside the Yangtze River Economic Belt，and has become a support belt for leading the high quality development of the national economy. Innovation-driven and open development is the high quality development of industry. The main driving force. The regional differentiation of high quality industrial development in the Yangtze River Economic Belt is remarkable. Shanghai，Jiangsu，Wuhan，and Chongqing are the “highlands” for high quality industrial development in the Yangtze River Economic Belt. The high quality development of the Yangtze River Economic Belt is facing major bottlenecks such as weak industrial innovation drive capability，difficulty in industrial pollution control，low regional industrial synergy，and a comprehensive opening up pattern. To further promote the quality improvement of the industrial development of the Yangtze River Economic Belt，we should give full play to the leading role of innovation-driven industrial transformation and upgrading，increase efforts to promote industrial green development，lead regional industrial synergy development，and improve the international development level of manufacturing.