Since Reunification in 1999，the science and technology industry in Macau has developed rapidly under the guidance of the “One Country，Two Systems” principle. This article introduces the principal measures taken by Macau to promote the development of science and technology after Reunification，enumerates the progress it has made and discusses its deficiency as well as proposing the next strategic steps. At present，with the continuous efforts of the government，Macau’s scientific and technological development has made great progress. Though this began relatively late，there are still many aspects to be improved amidst a rapid advancement. With the recent publication of the Outline Development Plan for the Guangdong-Hong Kong-Macau Bay Area，Macau’s scientific and technological development is destined to take to a new level on the existing basis. Macau should seize the opportunity of the construction of the Bay Area to accomplish true autonomous innovation and help the Bay Area to become a world-class science and technology innovation centre.