Since cities along the Yangtze River became open in 1992，the Yangtze River Economic Belt has made substantial progress in the development of open economy. In recent years particularly，the middle and upper reaches have accelerated the pace of opening up，and explored and formed the new model of inland openness represented by the China Railway Express. This paves a solid foundation for creating a pattern of comprehensively opening up the Yangtze River Economic Belt. However，the existing pattern characterized by strong eastern areas and coastal areas and weak western areas and inland areas has not yet fundamentally changed. Three new and difficult problems have arisen in the coordination of opening up the eastern and western areas. Hence，there is still a long way to go to achieve the all-round opening-up of Yangtze River Economic Belt.