Since its founding，Israel has been in a prolonged state of hostility with Syria and these two countries have not established diplomatic relations by far. After the outbreak of the Syrian civil war in 2011，the proliferation of terrorism，the interference of great powers and regional powers，and the frequent border conflicts in this region，posed serious challenges to Israel’s security，and made the regional situation as well as Israel-Syria relations more complicated. In response，Israel didn’t follow its allies’ position to seek the overthrow of the Bashar regime，but took a generally neutral position with a variety of flexible measures，which gained some success to insure its security. Israel，on the one hand，resolutely opposed the military presence of Iran and Hezbollah in Syria and launched preemptive strikes to eliminate threats on the border and in Syria which were related to Iran and Hezbollah. On the other hand，Israel actively sought the supports of the United States and moderate Arab countries，and carefully handled its relations with Russia. However，the Golan Heights dispute，the influence of Iran and Hezbollah，the interventions from US and Russia constrained the effect of Israel’s policies on the Syrian crisis.