This paper summarizes and analyzes the construction experience of “wisdom blood station” in Yichang City，introduces the construction of “four platforms and one base” from the initial top design plan，and makes full use of Internet + thinking. With the help of the information platform to promote the innovation of blood collection and supply mode，for the vast number of unpaid blood donors and blood transfusion patients. Yichang city put the free blood donation work in the angle of “big health” and the overall situation of “big city” construction to carry on the overall plan. Focus on Yichang Municipal Committee，the municipal government vigorously promote the good opportunity of “Internet medical treatment” in Yichang，unified establishment of the city-level blood collection and supply platform system，so others can get the experience as reference.