Objective Investigation and analysis of the construction of blood transfusion department（blood bank）and clinical blood transfusion management in Shanghai to provide valuable reference data for the construction of blood transfusion department（blood bank）and clinical blood transfusion management decision. Methods166 medical institutions were investigated by Shanghai quality control center of clinical transfusion medicine to analysis current situation of blood transfusion department（blood bank）construction and clinical blood transfusion management. Results The blood transfusion department（blood bank）of various medical institutions can perform clinical blood transfusion with proper standards. However，the performance showed certain signs of imbalance in the region. The problems mainly focus on the following aspects：the clinical blood management committees further enhance its function；some blood transfusion departments（blood bank）are in short of equipment and blood transfusion medicine professionals；standardization of clinical blood transfusion medical records should be paid more attention. Conclusion A positive development status of department construction and clinical blood application management can be concluded from the our data analysis. However，issues still remain in some aspects such as the lack of blood transfusion medicine professionals，the demand of improving blood management standardization.