The development of HLA in the field of blood transfusion in China has experienced different stages. In the early stage，the national cooperation has promoted the construction and development of HLA laboratories，but then the HLA development entered the bottleneck period. With the re-launch of China Marrow Donor Program after 2000，HLA laboratories have developed rapidly in the blood transfusion field，but overall there is still uneven development in HLA laboratories in various regions. The routine work of HLA laboratories is mainly HLA/HPA genotyping and HLA/HPA antibody detection. The genotyping methods include PCR-SSP，PCR-SSO，PCR-SBT and NGS. In order to solve the platelet transfusion refractory，some blood centers have established a certain size of HLA/HPA genotype database of apheresis platelet donors，but their clinical application is insufficient. To promote the overall development of HLA-related work，domestic HLA laboratories should explore HLA test standardization，new diagnostic techniques，HLA-accurate blood transfusion，HLA-compatible platelet transfusion and new strategies in the future. Also，it is needed to systematically analyze the association between HLA genes and diseases，and explore the role of HLA genes in stem cell transplantation.