Health is the inevitable prerequisite of promoting the comprehensive development of human beings and the foundation of economic and social development. Science popularization in the medical industry is an indispensable part of implementing the “Healthy China 2030 Outline”，constructing a healthier China and improving public health awareness. At present，there are many unfavorable factors affecting and restricting the development of medical science popularization in China，including cultural traditions，macro-systematic factors and social mechanism，knowledge structure and the capacity of practitioners.

In recent years，with the rapid development of mobile Internet，the industry of payable knowledge was born and developed with vehemence. It may be an important breakthrough to solve the predicament of traditional medical science popularization，and the payable knowledge industry also puts forward new requirements for the ability of medical science popularization practitioners. By the means of literature analysis and questionnaire survey，this paper analyzes the key factors in the development of payable knowledge，the restrictive factors of traditional medical science popularization，the feasibility of payable medical science popularization，as well as the demand of the capacity of payable medical science knowledge for practitioners. This is to inject vitality into the development of medical science popularization and provide new ideas and methods for the development of medical science popularization in China.