The data verification and analysis results for the sustainable development system in China’s 100 large-and medium-sized cities in 2018 show that Shenzhen，Beijing，the Pearl River Delta city cluster and eastern coastal cities，as the most economically developed regions of China，remained to rank among the top in terms of sustainable development. The cities ranked among the top 10 in terms of sustainable development competitiveness included Zhuhai，Shenzhen，Beijing，Hangzhou，Guangzhou，Qingdao，Changsha，Nanjing，Ningbo and Wuhan. Zhuhai had ranked top in the previous two consecutive years. Compared with inland industrial cities，coastal cities had higher environment quality. While vigorously accelerating economic growth，cities of middle and western regions were faced with severe environmental pressure and backward in terms of resources and environment，consumption and emission，environmental governance and other indices，resulting in their last rankings in terms of sustainable development.