In “Made in China 2025”，green，low carbon，high quality and sustainability had become the main tone in the current development of the manufacturing industry. Chemical APIs were the basic strategic industry of China’s emerging in the manufacturing industry. Its development faced problems such as low industrial concentration，serious homogenization，vicious and disorderly competition，low carbon productivity，backward production technology and high environmental pressure. This report took the application program of Yili Chuanning Biotechnology Co.，Ltd. as a classic example. It built a green factory and implemented a new model of intelligent antibiotic intermediate manufacturing factory based on high environmental protection standards. By analyzing and researching it，a predictable optimal path choice was provided，to solve the development dilemma of chemical API industry，to accelerate the green transformation and upgrading of the chemical API industry and improve quality and efficiency，to promote the industry’s position in the global industrial value chain and its market competitiveness，and to achieve high-quality green sustainable development.