The manufacturing process of APIs created a large amount of “three wastes”，which put the pharmaceutical companies to confront serious environmental protection challenges. Practicing the concept of green pharmaceuticals，developing and applying clean production technologies，and reducing pollutant emissions from the source of the process were the core and key to green pharmaceuticals. In line with the principle of technology accessibility and lowest cost，based on the analysis of pollution sources in the manufacturing process，clean production，reclamation of wastes and harmless treatment were combined to formulate a whole process pollution control strategy for the whole life cycle of pharmaceutical manufacturing. Guided by this strategy，the efforts were put on breakthroughs and implementation of key technologies and integrated technologies for emission reduction and pollution control，to establish a management concept of precise control and optimization，realize the transformation of API manufacturing from quality and efficiency oriented to quality control and resource conservation oriented，and support the sustainable green development of the pharmaceutical industry.