Pharmaceutical excipients were the general name of the ingredients other than active ingredients in the preparations. The registration and filing of pharmaceutical excipients and the relevant review and approval were major measures for the whole-process supervision of drug production and quality in China. The total number of pharmaceutical excipients that were sold in the market in China was more than 500，and the registration processes for excipients with different specifications were long. Therefore，the research and development and service of multi-specification excipients had become the bottleneck of domestic excipients. The filing system could shorten the review and approval cycle，and promote and accelerate the application of pharmaceutical excipients with different specifications. This report described the significance of the registration and relevant review and approval of pharmaceutical excipients，reviewed the implementation and made predictions.