It is of great significance that Yangtze River Delta Integration has become a national strategy，which has brought both opportunities and challenges to Anhui. Anhui possesses both advantages and disadvantages in promoting the integrated development of Yangtze River Delta. Anhui，as an important member of Yangtze River Integration，should seek opportunities and meet challenges，tap into its potential and avoid pitfalls，find its roles and functions，strengthen efforts to fully link and cooperate with relevant provinces and municipalities in the Yangtze River Delta，and actively serve the national Belt and Road initiative and Yangtze River Economic Belt strategies，in order to develop itself into the West Gate of Yangtze River Delta Integration.