Under the new industrial technology revolution，the integration of large，medium and small enterprises has become a new trend. To promote the development of integration of large，medium and small enterprises，it is necessary to use the relevant platform to exchange the key factors among them，such as resource endowment，product services，market factors，etc. For Henan Province，we need to rely on large enterprises，small and medium-sized enterprises，micro-enterprises，universities，government departments and other main bodies to promote the flat development of large enterprise organizational structure，the precise service of public service platform for small and medium-sized enterprises，the standardized operation of innovation and entrepreneurship demonstration bases for small and micro enterprises，the open development of innovation and entrepreneurship incubation platforms in universities，and the coordinated development of the industrial cluster，thus，to stimulate the endogenous motivation of various innovation and entrepreneurship entities.