Starting from the innovation diffusion mechanism of beijing-tianjin-hebei region，this study attempts to explore whether the diffusion effect of innovation in beijing-tianjin-hebei region is significant，and further explore the key factors that influence the diffusion effect of innovation in beijing-tianjin-hebei region，so as to capture the right starting point for the collaborative innovation of the three regions. By building a spatial econometric model to measure the diffusion effect of innovation，and taking the Yangtze river delta as a reference，the comparative study found that the R&D investment，innovation absorption and transformation investment in the beijing-tianjin-hebei region had a relatively weak promoting effect on the overall innovation output of the region. The ability of the beijing-tianjin-hebei innovation to translate into economic benefits is weaker than that of the Yangtze river delta. On this basis，policy Suggestions such as layout innovation chain around key industrial chain，perfecting market mechanism and promoting high-quality collaborative innovation are put forward.