Xiongan New Area is targeting at building a national model of high-quality development area and a demonstration of innovative development according to China's New Development Principles.The New Area should take a different development road from traditional cities.Innovation-driven development is an inexhaustible driving force for its progress and high-quality development.The establishment of innovation centers by conglomerates in Xiongan New Area contributes to promoting the evolution of regional innovation system and innovative development.The paper provides an analysis of the significance of setting up innovation centers in Xiongan New Area by conglomerates.On the basis of drawing lessons from the relevant experience of innovation centers at home and abroad，the book puts forward the feasible scheme of setting up innovation centers from the aspects of general ideas，the design of five industrial innovation centers in Xiongan New Area，infrastructure，and the construction of medium and long-term system and mechanism，and others.