The report of the 19th National Congress of the Communist Party of China pointed out that the role of social organizations should be brought into play to achieve positive interaction among government governance，social regulation and residents' autonomy.Social work service is an important part of social governance，which is of great significance to strengthening society with a focus on ensuring and improving people's livelihood.This report starts from the connection between social work and philanthropy in Guangzhou.In the process of policy guidance，the development of social work and philanthropy is mutually complementary，and the reform is getting closer with time.The combination of “targeted poverty alleviation ＆ social work” has a certain reference effect on promoting and guiding social work in Guangzhou.Under the context of “targeted poverty alleviation + social work”，the principle of “party and government guidance，coordinated promotion，people-oriented，precision service，east-west cooperation，extensive participation，mass participation，helping others and self-help” can provide guidance for the promotion of social work in Guangzhou.