Guizhou Province enjoys a superior geographical position，suitable climatic conditions，abundant energy resources，and superior location conditions for the development of big data industry. Guizhou Province is facing a global wave of big data strategies. It is necessary to fully seize this opportunity to realize the economic and social development of Guizhou Province. The development path of big data industry in Guizhou Province mainly includes：creating a good industrial development environment by formulating policy planning and establishing specialized organizations；constructing an industrial development platform by creating big data exchanges and comprehensive experimental zones；and introducing well-known enterprises at home and abroad. Guizhou's big data core business，related business，and derivative business developed rapidly. The national big data comprehensive experimental area series exploration and practice has achieved certain results，and the big data industry agglomeration has achieved remarkable results. However，Guizhou's big data industry development industry also has weak development foundation and technology. And the lack of talent support，financial resources and other obvious shortcomings，the development of big data industry is subject to certain constraints.