Through the analysis of the current situation of the economic and social development in China's Tumen River Area，and by combing with the new situations and new trends that China's Tumen River Area's economic and social development sees the opening trend of North Korea，the continuous development of Polar Silk Road and the still growing fourth industrial revolution，the report analyzes the difficulties of China's Tumen River Area in the economic and social development such as limited economic strength，the road construction needs to be improved，the foreign investment modes and fields to be explored，the talent cultivation and the introduction systems to be improved，and further makes suggestions on pushing the regional economic development in China's Tumen River Area，the supply-side reform of infrastructure，directing the foreign investments into featured industries，creating the platform of cultivating and introducing talents，with the intentions of providing intellectual supports for the development of China's Tumen River Area.