Opportunities and challenges in economic development in the South Sichuan Economic Zone will coexist，and the economic growth rate will slow down steadily. However，as China's economy gradually enters the stage of high-quality development，the endogenous driving force for economic growth will gradually increase. The economic growth rate of Sichuan's Southern Economic Zone will be steadily slowing down. With the promotion of the “One Trunk Multi-Branch” and innovation-driven strategy in Sichuan Province and the implementation of the green development concept，Sichuan's Southern Economic Zone will achieve development goals such as optimization of industrial structure，improvement of ecological environment，and improvement of residents' income. Based on the background of economic development and its own development advantages，Sichuan's Southern Economic Zone should adhere to industrial transformation and upgrading，build a global open pattern，adhere to the concept of green development，adhere to urban and rural overall planning to narrow regional gaps，and contribute to the realization of Sichuan's high-quality economic development.