Currently，with the development of economic globalization，the trans-regional cooperation has just been unfolding. This article has sorted out the definition of the trans-regional cooperation，reviewed the new development progress of the economic and trade situation between China and Portuguese Speaking Countries，and pointed out that China and Portuguese-Speaking Countries Economic Cooperation Forum （Macau） is the key starting point for Macau to promote regional cooperation by the trans-regional cooperation. Through the model of “Using linking places far away to integrate with neighboring regions”，it is very helpful for Macau to improve the city image，promoting the development of moderate economic diversification，and expanding the regional cooperation with the surrounding areas. At the same time，with the convening of the third ministerial conference of the Forum for Economic and Trade Cooperation between China and Portuguese-speaking Countries，it will reinforce to the Macau Platform Role between China and Portuguese Speaking Countries. For the new development situation，this article also presents some policy recommendations for the development of Macau Platform.