The global shipping industry spawned the imbalance between supply and demand，influenced by 2008's financial crisis in the U.S..The market imbalance leaded to shipping industrial crisis，which made the industry layout distribution change profoundly.The core of the global shipping industry is being pushed and towards East Asia.In this background，the bay area of Guangdong HK and Macau has several opportunities such as demands from new developing economies and challenges such as competing with local and foreign ports.The main cooperation mechanics and policy advise are，（1） setting up the infra-regional office of port cooperation.（2） enhancing cooperation with long-established shipping enterprise.（3） intensifying inland port's development.（4） outstanding the guidance suggestion in the Guangdong's FTZ general planning.（5） early warning work of shipping industrial crisis.